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Literature summary extracted from

  • Kohlhaas, J.; Jaeger, M.; Lust, L.; De La Torre, C.; Hecker, M.; Korff, T.
    Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression (2021), Exp. Cell Res., 399, 112446 .
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.1.21 medicine interaction with endothelial cells for 48 h down-regulates expression of genes in vascular smooth muscle cells controlling rate-limiting steps of the cholesterol biosynthesis such as HMG-CoA reductase, HMG-CoA-synthase-1, 24-dehydrocholesterol reductase and DHCR7. A decrease in the abundance of 24-dehydrocholesterol reductase and lower cholesterol levels in vascular smooth muscle cells cocultured with endothelial cells is observed Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.72 N,N-dimethyl-3beta-hydroxycholenamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.72 5alpha-cholest-7-en-3beta-ol + NADP+ Homo sapiens
-
 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Homo sapiens
-
-
-
1.3.1.72 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.21 smooth muscle cell
-
 Homo sapiens
-
1.3.1.72 HUASMC cell
-
 Homo sapiens
-
1.3.1.72 vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.72 5alpha-cholest-7-en-3beta-ol + NADP+
-
 Homo sapiens 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.72 24-dehydrocholesterol reductase
-
 Homo sapiens
1.3.1.72 DHCR24
-
 Homo sapiens
1.3.1.72 seladin-1
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.3.1.72 Homo sapiens vascular endothelial cells have the capacity to instruct vascular smooth muscle cells to shut down the expression of the enzyme thereby limiting their cholesterol biosynthesis down

General Information

EC Number General Information Comment Organism
1.3.1.21 physiological function interaction with endothelial cells for 48 h down-regulates expression of genes in vascular smooth muscle cells controlling rate-limiting steps of the cholesterol biosynthesis such as HMG-CoA reductase, HMG-CoA-synthase-1, 24-dehydrocholesterol reductase and DHCR7. A decrease in the abundance of 24-dehydrocholesterol reductase and lower cholesterol levels in vascular smooth muscle cells cocultured with endothelial cells is observed Homo sapiens
1.3.1.72 malfunction the blockade of the enzyme activity impairs adhesion, migration and proliferation of vascular smooth muscle cells Homo sapiens